Nba11^NZB
QTL Variant Detail

Summary

• QTL variant: Nba11^NZB
• Name: New Zealand Black autoimmunity 11; NZB
• MGI ID: MGI:3530768
• QTL: Nba11 Location: unknown Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: NZB

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to glomerulonephritis compared to SWR. (J:96263)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:96263

Linkage analysis was performed on 88 animals from a SWR x (SWR x NZB)F1 backcross population to identify QTLs associated with lupus phenotypes. (SWR x NZB)F1 hybrid animals are susceptible to lupus nephritis. Animals were sero-typed at 9-12 months of age. 116 autosomal microsatellite markers at an average spacing of 10.6 cM were used for the genome scan.

Suggestive linkage to glomerulonephritis mapped to 31 cM on mouse Chromosome 7 near D7Mit62 (LOD=1.93). This locus is thought to be the same as the previously identified Nba3. NZB-derived alleles at Nba3 confer susceptibility to glomerulonephritis with a dominant mode of inheritance.

07.17.2015 Curator Note: Because Nba3 was originally identified in J:23719 in 1995 using 90 female (NZB x SM/J)F1 x NZW backcross mice, which differs from the cross used here, we consider the current study a separate mapping experiment and have named this QTL Nba11.

Suggestive linkage to autoantibody production mapped to 52 cM on mouse Chromosome 7 near D7Mit12 (LOD=1.93). This locus is tentatively named Nba7. NZB-derived alleles confer increased autoantibody production with a dominant mode of inheritance.

References

• Original: J:96263 Xie S, et al., Dominant NZB contributions to lupus in the (SWR x NZB)F1 model. Genes Immun. 2002 Oct;3 Suppl 1:S13-20
• All: 1 reference(s)