Sertad2^{Gt(OST98734)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Sertad2^{Gt(OST98734)Lex}
• Name: SERTA domain containing 2; gene trap OST98734, Lexicon Genetics
• MGI ID: MGI:3530582
• Synonyms: Sertad2^{Gt(neo)490Lex}, TRIP-Br2 KO
• Gene: Sertad2 Location: Chr11:20493253-20603021 bp, + strand Genetic Position: Chr11, 13.03 cM, cytoband A3.2
• Alliance: Sertad2^{Gt(OST98734)Lex} page

Mutation origin

• Mutant Cell Line: OST98734
• Germline Transmission: Earliest citation of germline transmission: J:196054
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector inserted upstream of exon 3. Western blot analysis confirmed the absence of protein expression in epididymal fat tissue of mice fed a high fat diet. (J:196054)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST98734	CG524570 ; (MGI Seq Detail)	3' RACE	Chr11:20597806-20598312 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  83 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sertad2 Mutation: 81 strains or lines available

References

• Original: J:196054 Sim KG, et al., The TRIP-Br family of transcriptional regulators is essential for the execution of cyclin E-mediated cell cycle progression. Cell Cycle. 2006 May;5(10):1111-5
• All: 5 reference(s)