Gjc1^tm1.1Weil
Targeted Allele Detail

Summary

• Symbol: Gjc1^tm1.1Weil
• Name: gap junction protein, gamma 1; targeted mutation 1.2, Reto Weiler
• MGI ID: MGI:3530295
• Synonyms: Cx45del[EGFP]
• Gene: Gjc1 Location: Chr11:102690405-102710526 bp, - strand Genetic Position: Chr11, 66.48 cM
• Alliance: Gjc1^tm1.1Weil page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95984
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Crossing Gja7^tm1Weil with mice expressing cre in the germ line resulted in the excision of exon 3 by cre mediated recombination, leaving a single loxP site and an EGFP. (J:95984)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gjc1 Mutation: 35 strains or lines available

References

• Original: J:95984 Maxeiner S, et al., Deletion of connexin45 in mouse retinal neurons disrupts the rod/cone signaling pathway between AII amacrine and ON cone bipolar cells and leads to impaired visual transmission. J Neurosci. 2005 Jan 19;25(3):566-76
• All: 1 reference(s)