Tg(Prnp-SNCA*A30P)2Dpr
Transgene Detail

Summary

• Symbol: Tg(Prnp-SNCA*A30P)2Dpr
• Name: transgene insertion 2, Donald L Price
• MGI ID: MGI:3530128
• Synonyms: Hualpha-Syn(A30P), MoPrP-Hualpha-Syn(A30P), O2
• Transgene: Tg(Prnp-SNCA*A30P)2Dpr Location: unknown
• Alliance: Tg(Prnp-SNCA*A30P)2Dpr page

Transgene origin

• Strain of Origin: (C3H/HeJ x C57BL/6J)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-SNCA*A30P)2Dpr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

  Transgene codes for a protein with an alanine to proline mutation.

• Mutation details: The transgene contains human alpha synuclein cDNA encoding the Ala30Pro amino acid substitution, and the murine prion promoter. (J:77344)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Line T3 was also generated. Transgenic mice from both this line and line T3 express very high levels of mutant human A30P alpha synuclein in the brain, show significant somal accumulation of this protein, but do not develop neurological abnormalities. Even at advanced age, expression of the transgene in these mice does not lead to accumulation of ubiquitin in neurons.

References

• Original: J:77344 Lee MK, et al., Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8968-73
• All: 9 reference(s)