Tg(Prnp-SNCA)20Vle
Transgene Detail

Summary

• Symbol: Tg(Prnp-SNCA)20Vle
• Name: transgene insertion 20, Virginia M-Y Lee
• MGI ID: MGI:3530000
• Synonyms: M20
• Transgene: Tg(Prnp-SNCA)20Vle Location: unknown
• Alliance: Tg(Prnp-SNCA)20Vle page

Transgene origin

• Strain of Origin: C57BL/6 x C3H

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-SNCA)20Vle expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: The transgene contains wild-type human alpha synuclein cDNA and the mouse prion protein (Prnp) gene promoter together with its 5' untranslated region (UTR) containing an intron, and its 3' untranslated sequences. Transgene expression was detected in the cerebral cortex, spinal cord, and cerebellum. (J:76657)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

This transgenic line, originally designated M20, has the highest level of expression. Transgenic lines M7 and M12 were also generated.

References

• Original: J:76657 Giasson BI, et al., Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron. 2002 May 16;34(4):521-33
• All: 13 reference(s)