Tg(Th-SNCA*A30P)7Jbsc
Transgene Detail

Summary

• Symbol: Tg(Th-SNCA*A30P)7Jbsc
• Name: transgene insertion 7, Joerg B Schulz
• MGI ID: MGI:3528996
• Synonyms: TH-A30P7
• Transgene: Tg(Th-SNCA*A30P)7Jbsc Location: unknown
• Alliance: Tg(Th-SNCA*A30P)7Jbsc page

Transgene origin

• Strain of Origin: (DBA x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Th-SNCA*A30P)7Jbsc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

  Transgene codes for a protein with an alanine to proline mutation.

• Tg(Th-SNCA*A30P)7Jbsc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Th (25085)

  Th	(MGI:98735)

• Mutation details: The transgene contains 4.5 kb of rat tyrosine hydroxylase (Th) promoter sequences, a human alpha synuclein (SNCA) cDNA encoding an Ala30Pro amino acid substitution, an SV40 small t splice site, and SV40 polyadenylation sequences. (J:69529)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Transgenic mice did not show loss of Th-positive neurons or striatal dopamine. These mice did not show increased sensitivity to MPTP, not did they display any change in rotarod performance.

References

• Original: J:69529 Rathke-Hartlieb S, et al., Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice. J Neurochem. 2001 May;77(4):1181-4
• All: 1 reference(s)