Slc30a7^Gt(XC827)Byg
Gene trapped Allele Detail

Summary

• Symbol: Slc30a7^Gt(XC827)Byg
• Name: solute carrier family 30 (zinc transporter), member 7; gene trap XC827, BayGenomics
• MGI ID: MGI:3528432
• Synonyms: Znt7^-
• Gene: Slc30a7 Location: Chr3:115732622-115801055 bp, - strand Genetic Position: Chr3, 50.16 cM, cytoband G2
• Alliance: Slc30a7^Gt(XC827)Byg page

Mutation origin

• Mutant Cell Line: XC827
• Germline Transmission: Earliest citation of germline transmission: J:128927
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: A beta-geo trap vector inserted into intron 6 of the gene and deleted exon 7, intron 7 and a portion of exon 8. The deletion is predicted to truncate the protein at amino acid 221, which is upstream of two potential transmembrane domains predicted to be necessary for protein function. Only expression of mutant transcript was detected by Northern blots of RNA from the small intestine of homozygotes. (J:128927)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XC827	CC178383 ; (MGI Seq Detail)	5' RACE	Chr3:115778474-115786614 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  3 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Slc30a7^Gt(XC827)Byg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc30a7 Mutation: 21 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:128927 Huang L, et al., Znt7 (Slc30a7)-deficient Mice Display Reduced Body Zinc Status and Body Fat Accumulation. J Biol Chem. 2007 Dec 21;282(51):37053-63
• All: 9 reference(s)