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Transgene Detail
Symbol: Tg(TcraCDC35)1Alhn
Name: transgene insertion 1, Agnes Lehuen
MGI ID: MGI:3528229
Synonyms: A8, Valpha8 Tg
Transgene: Tg(TcraCDC35)1Alhn  Location: unknown  
Alliance: Tg(TcraCDC35)1Alhn page
Strain of Origin:  NOD
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(TcraCDC35)1Alhn expresses 1 gene
Mutation detailsThe transgene contains the V-J exon from the rearranged Tcra gene of the (C3H/HeJ x DBA/2J)F1-derived, IA-d-restricted, rabbit immunoglobulin-specific CDC35 T-lymphocyte cell line. This V-J exon, in which Tcra-V8 is joined to Tcra-J37, was inserted into the 2B4alphaEH vector between a 2-kb germline DNA fragment from the Tcra-V11 5' flanking region, which contains the natural Tcra-V promoter, and a chimeric sequence comprising: a 681-bp fragment containing the immunoglobulin heavy chain enhancer; approximately 100 bp from the 5' end of the Tcra-J-C intron; and a 9.8-kb germline DNA fragment including 6 kb of Tcra-C 5'-flanking DNA, all of the Tcra constant-region exons, and 0.5 kb of 3'-flanking DNA. (J:93798)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:93559 Mars LT, et al., Cutting edge: V alpha 14-J alpha 281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice. J Immunol. 2002 Jun 15;168(12):6007-11
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
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