Tg(MYC)1Led
Transgene Detail

Summary

• Symbol: Tg(MYC)1Led
• Name: transgene insertion 1, Philip Leder
• MGI ID: MGI:3528159
• Synonyms: EnMyc, TG.EB
• Transgene: Tg(MYC)1Led Location: unknown Genetic Position: Chr10, Syntenic
• Alliance: Tg(MYC)1Led page

Transgene origin

• Strain of Origin: CD-1 x C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contained a 12 kb fragment with the human cMYC promoter and coding sequence. A 1 kb fragment containing the murine immunoglobulin heavy chain enahancer sequence was inserted in the MYC intron 1 to direct transgene expression to B cell precursor cells. Transgene expression was found in the bone marrow, spleen, and thymus at 1 month of age. Expression in the thymus and spleen is virtually lost in older mice. Transgene expression was not detected in the brain, salivary glands, breast, muscle, lung, heart, stomach, small bowel, large bowel, pancreas, kidney, adrenal gland, ovary, testis, or epididymus. (J:93841)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MYC)1Led

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:93841 Schmidt EV, et al., Transgenic mice bearing the human c-myc gene activated by an immunoglobulin enhancer: a pre-B-cell lymphoma model. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6047-51
• All: 3 reference(s)