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Tg(Pim1-E2F2)6Rebr
Transgene Detail
Summary
Symbol: Tg(Pim1-E2F2)6Rebr
Name: transgene insertion 6, Rene Bernards
MGI ID: MGI:3527199
Synonyms: Eu-pp-E2F2, TEF2-6
Transgene: Tg(Pim1-E2F2)6Rebr  Location: unknown  
Alliance: Tg(Pim1-E2F2)6Rebr page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Pim1-E2F2)6Rebr expresses 1 gene
 
Tg(Pim1-E2F2)6Rebr expression driven by 1 gene
 
Mutation detailsA human E2F2 cDNA was cloned downstream of a murine Pim1 promoter in which a duplicated immunoglobulin heavy chain enhancer sequence was inserted. The polyA sequence was contributed by the Molony Murine Leukemia Virus. The founder carrying this allele failed to transmit the transgene to any of its offspring. (J:88864)
Tumor Data
List all tumor models in MMHCdb carrying Tg(Pim1-E2F2)6Rebr
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:88864 Scheijen B, et al., High incidence of thymic epithelial tumors in E2F2 transgenic mice. J Biol Chem. 2004 Mar 12;279(11):10476-83
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
02/20/2024
MGI 6.23
The Jackson Laboratory