Mybpc3^tm1Rmos
Targeted Allele Detail

Summary

• Symbol: Mybpc3^tm1Rmos
• Name: myosin binding protein C, cardiac; targeted mutation 1, Richard L Moss
• MGI ID: MGI:3526881
• Synonyms: cMyBP-C^-
• Gene: Mybpc3 Location: Chr2:90948489-90966861 bp, + strand Genetic Position: Chr2, 50.44 cM, cytoband E1
• Alliance: Mybpc3^tm1Rmos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95725
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 through 10 were replaced with a neomycin resistance cassette. Truncated transcription products were identified by Northern blot analysis. No protein products could be identified on Western blots. (J:95725)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mybpc3 Mutation: 41 strains or lines available

Notes

ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl⁺) or AB2.2 (129S7/SvEvBrd-Hprt^b-m2).

References

• Original: J:95725 Harris SP, et al., Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice. Circ Res. 2002 Mar 22;90(5):594-601
• All: 39 reference(s)