Cacna1e^tm1Tsch
Targeted Allele Detail

Summary

• Symbol: Cacna1e^tm1Tsch
• Name: calcium channel, voltage-dependent, R type, alpha 1E subunit; targeted mutation 1, Toni Schneider
• MGI ID: MGI:3526822
• Synonyms: Cav2.3(fl)
• Gene: Cacna1e Location: Chr1:154266477-154760247 bp, - strand Genetic Position: Chr1, 66.14 cM
• Alliance: Cacna1e^tm1Tsch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95636
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank exon 2 with loxP sites. Transient cre expression removed a floxed neo inserted into intron 2. Exon 2 encodes the first transmembrane segment of domain 1 and the adjacent loop to IS2. (J:95636)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cacna1e Mutation: 102 strains or lines available

References

• Original: J:95636 Pereverzev A, et al., Disturbances in glucose-tolerance, insulin-release, and stress-induced hyperglycemia upon disruption of the Ca(v)2.3 (alpha 1E) subunit of voltage-gated Ca(2+) channels. Mol Endocrinol. 2002 Apr;16(4):884-95
• All: 7 reference(s)