Dusp6^tm1Sms
Targeted Allele Detail

Summary

• Symbol: Dusp6^tm1Sms
• Name: dual specificity phosphatase 6; targeted mutation 1, Suzanne L Mansour
• MGI ID: MGI:3526178
• Synonyms: Dusp6^L
• Gene: Dusp6 Location: Chr10:99099093-99103351 bp, + strand Genetic Position: Chr10, 51.13 cM, cytoband C3
• Alliance: Dusp6^tm1Sms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117073
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZtAceCreNeo cassette was inserted in frame into exon 1 and a stop codon was placed in exon 3. The tAceCreNeo cassette was automatically excised during germline transmission of the mutant allele. Northern blot analysis confirmed the absence of transcription. Expression of LacZ is very low or absent in heterozygotes but present in homozygotes. (J:117073)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dusp6 Mutation: 27 strains or lines available

References

• Original: J:117073 Li C, et al., Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development. Development. 2007 Jan;134(1):167-76
• All: 2 reference(s)