Ahl3^MSM
QTL Variant Detail

Summary

• QTL variant: Ahl3^MSM
• Name: age related hearing loss 3; MSM
• MGI ID: MGI:3526113
• QTL: Ahl3 Location: Chr17:67203957-67204103 bp Genetic Position: Chr17, cM position of peak correlated region/allele: 38.15 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: MSM

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to age related hearing loss compared to C57BL/6J. (J:94762)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94762

A panel of 12 consomic mouse lines were used to map age related hearing loss. The consomic lines consist of whole MSM-derived chromosomes on a C57BL/6J genetic background. Currently there are 12 incomplete consomic lines where the mice are either homozygous or heterozygous for an MSM-derived chromosome. Parental strain C57BL/6J exhibits age related hearing loss beginning at 10 months of age whereas parental strain MSM is resistant to age related hearing loss.

A consomic line for MSM-derived chromosome 17 showed resistance to age related hearing loss at 18 months of age. Heterozygous chromosome 17 consomic mice were backcrossed to C57BL/6J and linkage analysis was performed. Peak linkage occurred near D17Mit119 (38.5 cM) with P=0.0023. This locus is named Ahl3 (age related hearing loss 3). The protective MSM-derived allele of Ahl3 appears to be dominant. Examination of chromosome 17 consomic mice revealed healthy stereocilia and outer hair cells at 16 months of age. Background strain C57BL/6J usually exhibits irregular sterocilia and incomplete loss of outer hair cells by that age.

References

• Original: J:94762 Nemoto M, et al., Ahl3, a third locus on mouse chromosome 17 affecting age-related hearing loss. Biochem Biophys Res Commun. 2004 Nov 26;324(4):1283-8
• All: 2 reference(s)