Ptf1a^tm1Mgn
Targeted Allele Detail

Summary

• Symbol: Ptf1a^tm1Mgn
• Name: pancreas specific transcription factor, 1a; targeted mutation 1, Mark A Magnuson
• MGI ID: MGI:3526067
• Synonyms: Ptf1a^LCA
• Gene: Ptf1a Location: Chr2:19450474-19452312 bp, + strand Genetic Position: Chr2, 13.37 cM, cytoband A2
• Alliance: Ptf1a^tm1Mgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306470
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, RMCE-ready)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a floxed neo cassette. This insertion results in the floxed cassette acceptor (LCA) available for recombinase-mediated cassette exchange (RMCE). (J:135698)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptf1a Mutation: 29 strains or lines available

References

• Original: J:135698 Burlison JS, et al., Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev Biol. 2008 Apr 1;316(1):74-86
• All: 2 reference(s)