Rasgrp3^{Gt(Pt1-ATG)1Vb}
Gene trapped Allele Detail

Summary

• Symbol: Rasgrp3^{Gt(Pt1-ATG)1Vb}
• Name: RAS, guanyl releasing protein 3; gene trap 1, Victoria L Bautch
• MGI ID: MGI:3525522
• Synonyms: Rasgrp3^-
• Gene: Rasgrp3 Location: Chr17:75742891-75836049 bp, + strand Genetic Position: Chr17, 46.55 cM
• Alliance: Rasgrp3^{Gt(Pt1-ATG)1Vb} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95118
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector containing a lacZ and its own start codon deleted exon 3 and therefore created a null allele. Northern blot analysis failed to detect any mRNA in E9.5 homozygous embryos (J:95118)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rasgrp3 Mutation: 42 strains or lines available

References

• Original: J:95118 Roberts DM, et al., A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters. Mol Cell Biol. 2004 Dec;24(24):10515-28
• All: 2 reference(s)