Tg(Col2a1-Hdac4)1Eno
Transgene Detail

Summary

• Symbol: Tg(Col2a1-Hdac4)1Eno
• Name: transgene insertion 1, Eric N Olson
• MGI ID: MGI:3525223
• Synonyms: alpha1(II)-HDAC4
• Transgene: Tg(Col2a1-Hdac4)1Eno Location: unknown
• Alliance: Tg(Col2a1-Hdac4)1Eno page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Col2a1-Hdac4)1Eno expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hdac4 (MGI:3036234)

• Mutation details: Expression of a signal resistant mutant form of Hdac4 in which serines 246, 467, and 632 were replaced with alanines was driven by the a 3 kb fragment of the Col2a1 promoter and the Col2a1 3 kb chondrocyte-specific enhancer region. Expression of the transgene was seen in proliferating chondrocytes. (J:94631)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:94631 Vega RB, et al., Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell. 2004 Nov 12;119(4):555-66
• All: 1 reference(s)