Tg(Ovgp1-TAg)1Imiy
Transgene Detail

Summary

• Symbol: Tg(Ovgp1-TAg)1Imiy
• Name: transgene insertion 1, Ichiro Miyoshi
• MGI ID: MGI:3522655
• Synonyms: mogp1-Tag
• Transgene: Tg(Ovgp1-TAg)1Imiy Location: unknown
• Alliance: Tg(Ovgp1-TAg)1Imiy page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The SV40 large T antigen was placed under the transcriptional control of a 2.2 kb fragment containing the mouse oviductal glycoprotein 1 (Ovgp1) gene promoter sequence. 3' UTR and polyA sequences were derived from the rabbit Beta globin gene. RT-PCR confirmed SV40 TAg expression in the oviduct, uterus, vagina, and ovary, but not in the brain, lung, heart, liver, kidney, spleen, stomach, muscle, spinal cord, lymph node, mammary gland, or fat tissue. (J:78481)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Ovgp1-TAg)1Imiy

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

The transgenic line was maintained in the paternal germline since transgenic females developed severe uterine tumor pathology by 6 weeks of age. A small number of males greater than 6 months of age developed prostate tumors.

References

• Original: J:78481 Miyoshi I, et al., Mouse transgenic for murine oviduct-specific glycoprotein promoter-driven simian virus 40 large T-antigen: Tumor formation and its hormonal regulation. Mol Reprod Dev. 2002 Oct;63(2):168-76
• All: 5 reference(s)