Cmcs^DBA/2
QTL Variant Detail

Summary

• QTL variant: Cmcs^DBA/2
• Name: cerebral malaria susceptibility in CBA/N; DBA/2
• MGI ID: MGI:3522315
• QTL: Cmcs Location: unknown Genetic Position: Chr17, cM position of peak correlated region/allele: 17.98 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/2

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to P. berghei ANKA infection compared to CBA/N. (J:94127)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94127

Linkage analysis was performed on a population of (CBA/N x DBA/2)F1 x CBA/N backcross animals to map QTLs associated with susceptibility to cerebral malaria. Parental strain CBA/N is susceptible to infection with Plasmodium berghei ANKA and die within 14days post-infection. Parental strain DBA/2 and (CBA/N x DBA/2)F1 hybrids are relatively resistant to P. berghei ANKA infection. 65 polymorphic markers covering 70% of the genome were used in the genome scan. Male backcross animals were infected with 1 x 10(6) P. berghei ANKA infected erythrocytes at 8-10 weeks of age.

A locus named Cmcs (cerebral malaria susceptibility in CBA/N) mapped to mouse Chromosome 17 near the H2 locus. Peak linkage occurs at 18.44 cM near D17Mit28 (P<0.0001). CBA/N-derived alleles confer susceptibility to P. berghei ANKA infection at Cmcs whereas DBA/2-derived alleles confer resistance. Candidate genes mapping near Cmcs include Tnf (19 cM), Lta (19 cM), H2-K, H2-Aa (18.65 cM), and H2-Ea (18.7 cM).

References

• Original: J:94127 Ohno T, et al., Detection of a new cerebral malaria susceptibility locus, using CBA mice. Immunogenetics. 2004 Dec;56(9):675-8
• All: 1 reference(s)