Etan1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Etan1^C57BL/6J
• Name: ether anesthesia 1; C57BL/6J
• MGI ID: MGI:3522106
• QTL: Etan1 Location: unknown Genetic Position: Chr7, cM position of peak correlated region/allele: 43.46 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to ether anesthesia compared to MSM/Ms. (J:94250)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94250

Linkage analysis was performed on 196 (C57BL/6J x MSM/Ms)F1 x MSM/Ms backcross animals to identify QTLs influencing sensitivity to ether anesthesia. Parental strain C57BL/6J exhibits resistance to ether anesthesia whereas parental strain MSM/Ms is sensitive. (C57BL/6J x MSM/Ms)F1 hybrids are resistant to ether anesthesia. An initial screen was done with 40 microsatellite markers using 12 resistant and 12 sensitive backcross animals. Linkage was detected on mouse Chromosomes 3, 7, and 8. More markers weretyped in the remaining animals and mouse Chromosome 7 showed the strongest linkage between 23 cM (D7Mit313) and 29 cM (D7Nds1). Peak linkage occurred near D7Nds1 with LOD=3.03. This locus is named Etan1 (ether anesthesia 1). Animals heterozygous at Etan1 are resistant to ether anesthesia compared animals homozygous for MSM/Ms-derived alleles. Potential candidate genes mapping near Etan1 are Gabrg3 (28.2 cM), Gabra5 (28.5 cM), Gabrb2 (28.6 cM), and Chrna7 (30 cM).

References

• Original: J:94250 Megumi T, et al., Mapping of putative ether-anesthesia resistance gene using C57BL/6J and MSM/Ms mouse strains. J Anesth. 2004;18(4):267-76
• All: 1 reference(s)