Scq1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Scq1^C57BL/6J
• Name: spinal cord QTL 1; C57BL/6J
• MGI ID: MGI:3521950
• QTL: Scq1 Location: unknown Genetic Position: Chr15, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:93691

Linkage analysis was performed to identify QTLs associated with spinal cord weight and cross sectional area. 100 phenotypically extreme animals from an (A/J x C57BL/6J)F2 intercross were used for initial linkage analysis. Parental strain A/J exhibits small spinal cords whereas parental strain C57BL/6J exhibits large spinal cords. 87 microsatellite markers at an average spacing of 16 cM were used for the genome scan.

The strongest linkage was detected at 47 cM on mouse Chromosome 15 near D15Mit158 (LOD=3.43). This locus is named Scq1 (spinal cord QTL 1). Scq1 affects both spinal cord weight and cross sectional area and appears to have an additive effect. This locus accounts for 24% of the phenotypic variance.

Two other suggestive loci mapped to 19 cM and 45 cM on mouse Chromosome X near DXMit140 and DXMit64, respectively. These loci are tentatively named Scq2 (DXMit140) and Scq3 (DXMit64) and are associated with spinal cord weight. Scq2 accounts for 19% of the phenotypic variance while Scq3 accounts for15% of the phenotypic variance. The LOD scores for Scq2 and Scq3 are 2.69 and 2.19, respectively.

References

• Original: J:93691 Tan XL, et al., Identification of QTLs for weight and cross-sectional area on cervical enlargement of spinal cord in mice. Yi Chuan Xue Bao. 2004 Aug;31(8):801-6
• All: 1 reference(s)