Klf11^tm1Czs
Targeted Allele Detail

Summary

• Symbol: Klf11^tm1Czs
• Name: Kruppel-like transcription factor 11; targeted mutation 1, Chao-Zhong Song
• MGI ID: MGI:3513147
• Synonyms: KLF11-
• Gene: Klf11 Location: Chr12:24701370-24712781 bp, + strand Genetic Position: Chr12, 8.49 cM
• Alliance: Klf11^tm1Czs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94499
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exons 3 and 4 were replaced by a PGK-neomycin resistance cassette. RT-PCR confirmed that transcription no longer occurred. (J:94499)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf11 Mutation: 34 strains or lines available

References

• Original: J:94499 Song CZ, et al., Functional study of transcription factor KLF11 by targeted gene inactivation. Blood Cells Mol Dis. 2005 Jan-Feb;34(1):53-9
• All: 19 reference(s)