Fmgty14^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Fmgty14^C57BL/6J
• Name: femur geometry 14; C57BL/6J
• MGI ID: MGI:3513023
• QTL: Fmgty14 Location: unknown Genetic Position: Chr17, cM position of peak correlated region/allele: 12.53 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased minimum outer fiber length (MinOFL), maximum outer fiber length (MaxOFL), average outer fiber length (AveOFL), medial/lateral axis bending moment of inertia (Iml), and anterior/posterior bending moment of inertia (Iap) compared to BALB/cJ. (J:94352)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94352

487 animals from a heterogeneous stock designated UM-HET3 were analyzed for bone (femur) geometry traits. UM-HET3 is derived from a cross between (BALB/cJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1. 99 polymorphic markers at an average spacing of 15 cM - 20 cM were used in the genome scan. Nine geometric traits were evaluated for each femur.

Linkage to minimum outer fiber length (MinOFL), maximum outer fiber length (MaxOFL), average outer fiber length (AveOFL), medial/lateral axis bending moment of inertia (Iml), and anterior/posterior bending moment of inertia (Iap) map to 11.7 cM on mouse Chromosome 17 near D17Mit46. This locus is designated Fmgty14. C57BL/6J-derived alleles confer increased MinOFL, MaxOFL, AveOFL, Iml, and Iap compared to BALB/cJ-derived alleles.

References

• Original: J:94352 Volkman SK, et al., Quantitative trait loci for femoral size and shape in a genetically heterogeneous mouse population. J Bone Miner Res. 2003 Aug;18(8):1497-505
• All: 1 reference(s)