repro2
Chemically induced Allele Detail

Summary

• Symbol: repro2
• Name: reproductive mutant 2, JAX Reproductive Mutagenesis Program
• MGI ID: MGI:3512896
• Synonyms: G1-374-15
• Gene: repro2 Location: Chr5:119945037-123550137 bp Genetic Position: Chr5, Syntenic
• Alliance: repro2 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This phenotypic mutant was identified in an ENU mutagenesis screen.
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any repro2 Mutation: 0 strains or lines available

Notes

Males are infertile: very low epididymal sperm concentration, many sperm have abnormally shaped heads or no heads, sperm tails are short or curled, no sperm motility, no IVF success. Histological analysis shows abnormal spermiogenesis characterized by abnormally shaped spermatid heads and abnormal tail morphology.

References

• Original: J:117563 Lessard C, et al., Mutagenesis-generated mouse models of human infertility with abnormal sperm. Hum Reprod. 2007 Jan;22(1):159-66
• All: 2 reference(s)