Txnrd2^tm2Marc
Targeted Allele Detail

Summary

• Symbol: Txnrd2^tm2Marc
• Name: thioredoxin reductase 2; targeted mutation 2, Marcus Conrad
• MGI ID: MGI:3512410
• Gene: Txnrd2 Location: Chr16:18245167-18297823 bp, + strand Genetic Position: Chr16, 11.41 cM
• Alliance: Txnrd2^tm2Marc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94136
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The last 4 exons containing the C-terminal catalytic center were flanked with loxP sites and an IRES-lacZ cassette inserted such that after cre mediated recombination beta-galactosidase expression is controlled by the endogenous promoter. (J:94136)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Txnrd2 Mutation: 18 strains or lines available

References

• Original: J:94136 Conrad M, et al., Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol Cell Biol. 2004 Nov;24(21):9414-23
• All: 1 reference(s)