Th^tm2Te
Targeted Allele Detail

Summary

• Symbol: Th^tm2Te
• Name: tyrosine hydroxylase; targeted mutation 2, Ted Ebendal
• MGI ID: MGI:3487230
• Synonyms: B2+(Th-IRES-BMPR2trunc-neo+), TEb-1
• Gene: Th Location: Chr7:142446516-142453732 bp, - strand Genetic Position: Chr7, 88.06 cM
• Alliance: Th^tm2Te page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93552
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Hypomorph, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A DNA segment encoding a truncated version of bone morphogenic protein receptor, type II (serine/threonine kinase), preceded by an internal ribosome entry site (IRES) and followed by a frt-flanked neomycin resistance cassette, was introduced into the 3' untranslated region of the endogenous tyrosine hydroxylase gene. In situ hybridization and immunohistochemcal analysis revealed reduction in the levels of tyrosine hydroxylase mRNA and protein in brains of homozygous mice. (J:93552)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Th Mutation: 57 strains or lines available

References

• Original: J:93552 Althini S, et al., Normal nigrostriatal innervation but dopamine dysfunction in mice carrying hypomorphic tyrosine hydroxylase alleles. J Neurosci Res. 2003 May 15;72(4):444-53
• All: 1 reference(s)