Tg(TF-CAT)48Gsa
Transgene Detail

Summary

• Symbol: Tg(TF-CAT)48Gsa
• Name: transgene insertion 48, Gwen S Adrian
• MGI ID: MGI:3056737
• Transgene: Tg(TF-CAT)48Gsa Location: unknown
• Alliance: Tg(TF-CAT)48Gsa page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: 1196 bp of promoter sequence (-1152 to + 46) from the human TF gene were used to drive the expression of a CAT reporter gene. The transgene was expressed at high levels in the liver and brain, with brain levels being 10-fold higher than in the liver. Iron administration mice resulted in a significant decrease of transgene expression. (J:93006)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:93006 Adrian GS, et al., Human transferrin. Expression and iron modulation of chimeric genes in transgenic mice. J Biol Chem. 1990 Aug 5;265(22):13344-50
• All: 1 reference(s)