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Targeted Allele Detail
Symbol: Ctnnd2tm1Lxin
Name: catenin delta 2; targeted mutation 1, Xin Liu
MGI ID: MGI:3056606
Synonyms: delta-cat-
Gene: Ctnnd2  Location: Chr15:30172739-31029487 bp, + strand  Genetic Position: Chr15, 12.02 cM
Alliance: Ctnnd2tm1Lxin page
Germline Transmission:  Earliest citation of germline transmission: J:93226
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsGFP followed by a stop codon and a PGK-hygro cassette were inserted within exon 9, preventing transcription of the carboxyl terminal region. Northern, western and immunohistochemical analysis confirmed a truncated RNA and the absence of protein in the brain. (J:93226)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ctnnd2 Mutation:  40 strains or lines available
Original:  J:93226 Israely I, et al., Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction. Curr Biol. 2004 Sep 21;14(18):1657-63
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory