Foxp1^tm1Eem
Targeted Allele Detail

Summary

• Symbol: Foxp1^tm1Eem
• Name: forkhead box P1; targeted mutation 1, Edward E Morrisey
• MGI ID: MGI:3056542
• Synonyms: Foxp4^Neo
• Gene: Foxp1 Location: Chr6:98902299-99499682 bp, - strand Genetic Position: Chr6, 45.74 cM, cytoband E1
• Alliance: Foxp1^tm1Eem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93182
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 12, 13, and 14, that encode the forkhead DNA-binding domain, were replaced with a Neo cassette via homologous recombination. RT-PCR and immunohistochemistry confirmed absence of mRNA in embryos and protein in heart tissue. (J:93182)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxp1 Mutation: 75 strains or lines available

References

• Original: J:93182 Wang B, et al., Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation. Development. 2004 Sep;131(18):4477-87
• All: 11 reference(s)