Isl2^{tm1(Epha3)Grl}
Targeted Allele Detail

Summary

• Symbol: Isl2^{tm1(Epha3)Grl}
• Name: insulin related protein 2 (islet 2); targeted mutation 1, Greg Lemke
• MGI ID: MGI:3056440
• Synonyms: Isl2-EphA3
• Gene: Isl2 Location: Chr9:55445956-55453464 bp, + strand Genetic Position: Chr9, 30.13 cM, cytoband C
• Alliance: Isl2^{tm1(Epha3)Grl} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63516
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The coding sequence for Epha3 and a floxed neo cassette was inserted into the endogenous locus and placed under the regulatory elements of Isl2. The construct encoded a bicistronic mRNA as shown by in situ hybridization of neonates, showing a mosaic pattern of EphA3 expression that was similar to the pattern of endogenous Isl2 expression. Isl2 expression was not perturbed. (J:63516)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Isl2 Mutation: 28 strains or lines available

References

• Original: J:63516 Brown A, et al., Topographic mapping from the retina to the midbrain is controlled by relative but not absolute levels of EphA receptor signaling. Cell. 2000 Jul 7;102(1):77-88
• All: 13 reference(s)