Ret^tm1Mat
Targeted Allele Detail

Summary

• Symbol: Ret^tm1Mat
• Name: ret proto-oncogene; targeted mutation 1, Masahide Takahashi
• MGI ID: MGI:3055332
• Synonyms: c-Ret-KI^Y1062F, Y1062F
• Gene: Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
• Alliance: Ret^tm1Mat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92802
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: The introduction of a targeting vector resulted in two amino acid replacements, KLY¹⁰⁶² to KIF¹⁰⁶², within exon 19 and a floxed PGK-neo inserted into intron 19. RT-PCR indicated that the substitutions did not inhibit correct splicing in mutants, nor did the neo create significant differences in protein expression between mutant and wild-type mice. (J:92802)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ret Mutation: 53 strains or lines available

References

• Original: J:92802 Jijiwa M, et al., A targeting mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia. Mol Cell Biol. 2004 Sep;24(18):8026-36
• All: 7 reference(s)