F11r^tm1.1Dej
Targeted Allele Detail

Summary

• Symbol: F11r^tm1.1Dej
• Name: F11 receptor; targeted mutation 1.1, Elisabetta Dejana
• MGI ID: MGI:3054821
• Synonyms: Jam-a^-, JAM-A^-
• Gene: F11r Location: Chr1:171265129-171292161 bp, + strand Genetic Position: Chr1, 79.43 cM, cytoband H2
• Alliance: F11r^tm1.1Dej page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92592
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Crossing F11r^tm1Dej mice with mice expressing cre in the germ line resulted in the excision of the floxed region including exon 1. Absence of protein was confirmed by FACS analysis of leukocytes and endothelial cells, Western blot and histological analysis of different organs. (J:92592)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F11r Mutation: 28 strains or lines available

References

• Original: J:92592 Cera MR, et al., Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice. J Clin Invest. 2004 Sep;114(5):729-38
• All: 23 reference(s)