Tg(H2-K-Fos)1Wag
Transgene Detail

Summary

• Symbol: Tg(H2-K-Fos)1Wag
• Name: transgene insertion 1, Erwin F Wagner
• MGI ID: MGI:3054664
• Synonyms: H2-c-fos, Tg(H2-c-fos)
• Transgene: Tg(H2-K-Fos)1Wag Location: unknown
• Alliance: Tg(H2-K-Fos)1Wag page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-K-Fos)1Wag expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fos (MGI:95574)

• Mutation details: The transgene comprises a 4.1 kb genomic DNA fragment including the translation initiation codon, all exons and introns, and the polyadenylation signal of the mouse FBJ osteosarcoma [proto-] oncogene joined to a 2 kb fragment containing the promoter and the first nine transcribed base pairs of the mouse H2-K^b gene. All five transgenic lines expressed transgenic mRNA in spleen, thymus, lung and salivary gland, most at high levels; 4/5, at low to moderate levels, in liver and muscle; 3/5 at low levels in heart, gonads and kidney; one, at a low level, in pancreas; and none in brain or bone marrow. (J:92870)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

5 independent transgenic lines were generated from founders designated 247-1, 248-6, 248-7 and 263-3; two lines were derived from a single founder, 247-1, that had integrated the Tg in two sites. Little distinction is made among them in the original reference.

References

• Original: J:92870 Ruther U, et al., c-fos expression interferes with thymus development in transgenic mice. Cell. 1988 Jun 17;53(6):847-56
• All: 7 reference(s)