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Transgene Detail
Symbol: Tg(Mt1-RET)192Ina
Name: transgene insertion 192, Izumi Nakashima
MGI ID: MGI:3054014
Synonyms: Tg(Mt1-RET)192Num, Tg(Mt1-RFP/RET)192Num
Transgene: Tg(Mt1-RET)192Ina  Location: unknown  
Alliance: Tg(Mt1-RET)192Ina page
Strain of Origin:  (BALB/c x C57BL/6) X BALB/c
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Mt1-RET)192Ina expresses 1 gene
Mutation detailsThe transgene comprises the cDNA encoding the human ret proto-oncogene driven by the mouse metallothionein 1 promoter/enhancer and followed by a segment of the simian virus 40 (SV40) genome containing a splice signal, a polyadenylation signal and 3' flanking sequence. Northern blot analysis revealed high levels of transgene expression in tumors and varying levels in melanin-producing cells of other tissues in mice of this line, including skin, muscle and Harderian glands. (J:70622)
Tumor Data
List all tumor models in MMHCdb carrying Tg(Mt1-RET)192Ina
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Sublines 192A, 192B and 192C were derived by crossing early descendants of female founder 192, on a mixed BALB/c and C57BL/6 background, to C57BL/6, (BALB/c x C57BL/6)F1 or BALB/c mice, respectively, then intercrossing the progeny. Other founder lines were 108, 207, 242, 301, 304 and 319.
Original:  J:70622 Iwamoto T, et al., Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene. EMBO J. 1991 Nov;10(11):3167-75
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory