Tg(Mt1-RET)192Ina
Transgene Detail

Summary

• Symbol: Tg(Mt1-RET)192Ina
• Name: transgene insertion 192, Izumi Nakashima
• MGI ID: MGI:3054014
• Synonyms: Tg(Mt1-RET)192Num, Tg(Mt1-RFP/RET)192Num
• Transgene: Tg(Mt1-RET)192Ina Location: unknown
• Alliance: Tg(Mt1-RET)192Ina page

Transgene origin

• Strain of Origin: (BALB/c x C57BL/6) X BALB/c

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mt1-RET)192Ina expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RET (5979)

  Ret	(MGI:97902)

• Mutation details: The transgene comprises the cDNA encoding the human ret proto-oncogene driven by the mouse metallothionein 1 promoter/enhancer and followed by a segment of the simian virus 40 (SV40) genome containing a splice signal, a polyadenylation signal and 3' flanking sequence. Northern blot analysis revealed high levels of transgene expression in tumors and varying levels in melanin-producing cells of other tissues in mice of this line, including skin, muscle and Harderian glands. (J:70622)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Mt1-RET)192Ina

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Sublines 192A, 192B and 192C were derived by crossing early descendants of female founder 192, on a mixed BALB/c and C57BL/6 background, to C57BL/6, (BALB/c x C57BL/6)F1 or BALB/c mice, respectively, then intercrossing the progeny. Other founder lines were 108, 207, 242, 301, 304 and 319.

References

• Original: J:70622 Iwamoto T, et al., Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene. EMBO J. 1991 Nov;10(11):3167-75
• All: 3 reference(s)