Ahnak^tm1Tak
Targeted Allele Detail

Summary

• Symbol: Ahnak^tm1Tak
• Name: AHNAK nucleoprotein; targeted mutation 1, Junji Takeda
• MGI ID: MGI:3053964
• Gene: Ahnak Location: Chr19:8966648-9054278 bp, + strand Genetic Position: Chr19, 6.04 cM, cytoband A
• Alliance: Ahnak^tm1Tak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92500
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Homologous recombination was used to delete approximately 3.2 kb of sequence including the ATG start codon. Western blot and immunoprecipitation of skin sections confirmed that no protein was expressed in mutant mice. (J:92500)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ahnak Mutation: 316 strains or lines available

References

• Original: J:92500 Kouno M, et al., Ahnak/Desmoyokin is dispensable for proliferation, differentiation, and maintenance of integrity in mouse epidermis. J Invest Dermatol. 2004 Oct;123(4):700-7
• All: 5 reference(s)