Tg(SOD1)10Cje
Transgene Detail

Summary

• Symbol: Tg(SOD1)10Cje
• Name: transgene insertion 10, Charles J Epstein
• MGI ID: MGI:3053950
• Synonyms: 218/10, TgHS-218/10
• Transgene: Tg(SOD1)10Cje Location: unknown
• Alliance: Tg(SOD1)10Cje page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SOD1)10Cje expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOD1 (6647)

  Sod1	(MGI:98351)

• Mutation details: The entire human SOD1 sequence was used for the transgene. Eight copies of the transgene inserted into Chromosome 10 (J:18645). Northern blot analysis of brain and liver from transgenic animals showed expression of 0.9 kb and 0.7 kb transcripts similar to that in humans. Transgenic animals exhibited increased enzyme activity in nearly all tissues examined. (J:30458)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Line 3 was also produced.

Transgenic mice on a C57BL/6 background are viable. Although homozygote males are sterile, homozygote females are fertile.

Transgenic mice express three times the normal level of SOD1 in the blood, brain, and fibroblasts.

References

• Original: J:30458 Epstein CJ, et al., Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome. Proc Natl Acad Sci U S A. 1987 Nov;84(22):8044-8
• All: 5 reference(s)