Tnfrsf13b^tm1Cmac
Targeted Allele Detail

Summary

• Symbol: Tnfrsf13b^tm1Cmac
• Name: tumor necrosis factor receptor superfamily, member 13b; targeted mutation 1, Charles R Mackay
• MGI ID: MGI:3052983
• Synonyms: TACI^-
• Gene: Tnfrsf13b Location: Chr11:61017581-61040198 bp, + strand Genetic Position: Chr11, 37.96 cM
• Alliance: Tnfrsf13b^tm1Cmac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91914
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A tailless human CD2 reporter cDNA and PGK-neo replaced 6.12 kb immediately downstream of the ATG, including nucleotides encoding amino acids 1-89. As a result, stop codons were introduced in each possible reading frame downstream of the inserted reporter. (J:91914)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf13b Mutation: 18 strains or lines available

References

• Original: J:91914 Ng LG, et al., B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol. 2004 Jul 15;173(2):807-17
• All: 6 reference(s)