Rr105^tm1Bas
Targeted Allele Detail

Summary

• Symbol: Rr105^tm1Bas
• Name: regulatory region 105; targeted mutation 1, Claudio Basilico
• MGI ID: MGI:3052219
• Synonyms: Fgf4^delta3a, Fgf4^tm1Bas
• Gene: Rr105 Location: unknown Genetic Position: Chr7, Syntenic
• Alliance: Rr105^tm1Bas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92206
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The conserved Hom3a enhancer elements in the 3' UTR of Fgf4 were deleted. A loxP site flanked neomycin resistance gene cassette was inserted and subsequently excised by crossing with CMV-Cre mice, leaving a single loxP site. Southern blot indicated correct recombination in homozygous mice. (J:92206)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr105 Mutation: 0 strains or lines available

References

• Original: J:92206 Iwahori A, et al., A conserved enhancer element that drives FGF4 gene expression in the embryonic myotomes is synergistically activated by GATA and bHLH proteins. Dev Biol. 2004 Jun 15;270(2):525-37
• All: 1 reference(s)