Hhat^tm1Ptch
Targeted Allele Detail

Summary

• Symbol: Hhat^tm1Ptch
• Name: hedgehog acyltransferase; targeted mutation 1, Pao-Tien Chuang
• MGI ID: MGI:3051900
• Synonyms: SkndeltaE2
• Gene: Hhat Location: Chr1:192195133-192453546 bp, - strand Genetic Position: Chr1, 97.55 cM
• Alliance: Hhat^tm1Ptch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89228
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2, which contains the ATG, and an FRT flanked PGK-neo with a loxP site and lacZ downstream. Crossing with Cre deleter mice creates this allele in which exon 2 and the neo are excised, leaving a lacZ and single loxP. (J:89228)

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hhat Mutation: 26 strains or lines available

References

• Original: J:89228 Chen MH, et al., Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev. 2004 Mar 15;18(6):641-59
• All: 2 reference(s)