Ptges^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Ptges^tm1Aki
• Name: prostaglandin E synthase; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3051640
• Synonyms: mPGES-1^-
• Gene: Ptges Location: Chr2:30779483-30793309 bp, - strand Genetic Position: Chr2, 21.75 cM
• Alliance: Ptges^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92047
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details:

  Exon 2 was replaced with a neomycin resistance gene. Mutant transcripts were detected by Northern blot of peritoneal macrophages. RT-PCR and sequencing confirmed that the mutant transcripts resulted from the deletion of the second exon and that the normal protein was not produced in mutant mice. (J:92047)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptges Mutation: 50 strains or lines available

References

• Original: J:92047 Uematsu S, et al., Lipopolysaccharide-dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway. J Immunol. 2002 Jun 1;168(11):5811-6
• All: 44 reference(s)