Socs3^tm1Ayos
Targeted Allele Detail

Summary

• Symbol: Socs3^tm1Ayos
• Name: suppressor of cytokine signaling 3; targeted mutation 1, Akihiko Yoshimura
• MGI ID: MGI:3051525
• Synonyms: Socs3^fl, Socs3^flox
• Gene: Socs3 Location: Chr11:117856905-117860192 bp, - strand Genetic Position: Chr11, 82.96 cM, cytoband E2
• Alliance: Socs3^tm1Ayos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92040
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted in intron 1 and in the 3' UTR of exon 2, thereby surrounding the coding sequence. Southern blot confirmed recombination. (J:92040)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Socs3 Mutation: 21 strains or lines available

References

• Original: J:92040 Yasukawa H, et al., IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol. 2003 Jun;4(6):551-6
• All: 85 reference(s)