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Targeted Allele Detail
Symbol: Socs3tm1Ayos
Name: suppressor of cytokine signaling 3; targeted mutation 1, Akihiko Yoshimura
MGI ID: MGI:3051525
Synonyms: Socs3fl, Socs3flox
Gene: Socs3  Location: Chr11:117856905-117860192 bp, - strand  Genetic Position: Chr11, 82.96 cM, cytoband E2
Alliance: Socs3tm1Ayos page
Germline Transmission:  Earliest citation of germline transmission: J:92040
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsLoxP sites were inserted in intron 1 and in the 3' UTR of exon 2, thereby surrounding the coding sequence. Southern blot confirmed recombination. (J:92040)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Socs3 Mutation:  21 strains or lines available
Original:  J:92040 Yasukawa H, et al., IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol. 2003 Jun;4(6):551-6
All:  86 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory