Ppl^tm1Aho
Targeted Allele Detail

Summary

• Symbol: Ppl^tm1Aho
• Name: periplakin; targeted mutation 1, Sirpa Aho
• MGI ID: MGI:3050592
• Synonyms: Ppl^-
• Gene: Ppl Location: Chr16:4904155-4950285 bp, - strand Genetic Position: Chr16, 2.5 cM, cytoband A-B1
• Alliance: Ppl^tm1Aho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91578
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 17 through 21 and part of 22, encoding residues 656 to 977, including the C-terminal end of the head domain and the N-terminal end of the rod domain, were replaced with a neo. Recombination was verified by Southern blot and PCR. Protein was not detected in mutants by Western blot. (J:91578)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppl Mutation: 85 strains or lines available

References

• Original: J:91578 Aho S, et al., Periplakin gene targeting reveals a constituent of the cornified cell envelope dispensable for normal mouse development. Mol Cell Biol. 2004 Jul;24(14):6410-8
• All: 7 reference(s)