Socs5^tm1Wsa
Targeted Allele Detail

Summary

• Symbol: Socs5^tm1Wsa
• Name: suppressor of cytokine signaling 5; targeted mutation 1, Warren S Alexander
• MGI ID: MGI:3050577
• Synonyms: Socs5^-
• Gene: Socs5 Location: Chr17:87415107-87445267 bp, + strand Genetic Position: Chr17, 56.93 cM
• Alliance: Socs5^tm1Wsa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91591
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The single coding exon was replaced with an unexpected duplication of the targeting vector containing one lacZ-floxed neo cassette such that two cassettes were inserted. Northern blotting and reverse transcription-PCR revealed absence of transcripts in all tissues examined. (J:91591)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Socs5 Mutation: 17 strains or lines available

References

• Original: J:91591 Brender C, et al., SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function. Mol Cell Biol. 2004 Jul;24(13):6094-103
• All: 3 reference(s)