Tg(MMTV-vHaras)4bPjo
Transgene Detail

Summary

• Symbol: Tg(MMTV-vHaras)4bPjo
• Name: transgene insertion 4b, Paul Jolicoeur
• MGI ID: MGI:3047074
• Synonyms: MMTV/v-Ha-ras, MR4B
• Transgene: Tg(MMTV-vHaras)4bPjo Location: unknown
• Alliance: Tg(MMTV-vHaras)4bPjo page

Transgene origin

• Strain of Origin: (C3H x C57BL/6)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contains the mouse mammary tumor virus promoter and an allele of the v-Ha-ras (Harvey rat sarcoma) viral oncogene carrying two activating point mutations: one in codon 12, Gly12Arg, and one in codon 59, Ala59Thr. (J:46456, J:90327)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTV-vHaras)4bPjo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Founders 2, 3, 4a, and 5 were also produced.

• The frequency of mammary gland adenocarcinomas for line 4b females on a genetic background that involves (C3H x C57BL/6)F2 and BALB/cJ is 83%.

• 87% of line 4b transgenic mice on a genetic background that involves (C3H x C57BL/6)F2 and BALB/cJ developed Harderian gland hyperplasia (eye).

• 62.5% of line 4b transgenic mice on a genetic background that involves (C3H x C57BL/6)F2 and BALB/cJ developed spleen red pulp hyperplasia.

References

• Original: J:46456 Tremblay PJ, et al., Transgenic mice carrying the mouse mammary tumor virus ras fusion gene: distinct effects in various tissues. Mol Cell Biol. 1989 Feb;9(2):854-9
• All: 2 reference(s)