Scfr3^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Scfr3^C57BL/6J
• Name: stem cell frequency regulator 3; C57BL/6J
• MGI ID: MGI:3046812
• QTL: Scfr3 Location: unknown Genetic Position: Chr18, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:42369

Quantitative Trait linkage analysis of stem cell frequency in BXD RI strains was informative in mapping Scfr3 to mouse Chromosome 18. DBA/2J mice had threefold higher CAFC (cobblestone area-forming cell) day 35 frequencies than C57BL/6J mice. A genome wide scan using BXD RI strains showed a statistical significant correlation of the gene controlling stem cell frequency with D18Ncvs22 on mouse Chromosome 18. The location of the gene controlling stem cell frequency reported here differs from a previously reported Quantitative Trait linkage analysis (J:32090, Muller-Sieburg CE; Riblet R, Genetic control of the frequncy of hematopoietic stem cells in mice: mapping of a candidate locus to Chromosome 1., J Exp Med 1996 Mar 1; 183(3):1141-50) in which this samephenotype was shown mapping with loci on mouse Chromosome 1.

References

• Original: J:42369 de Haan G, et al., Intrinsic and extrinsic control of hemopoietic stem cell numbers: mapping of a stem cell gene. J Exp Med. 1997 Aug 18;186(4):529-36
• All: 1 reference(s)