Fgg^tm2Jld
Targeted Allele Detail

Summary

• Symbol: Fgg^tm2Jld
• Name: fibrinogen gamma chain; targeted mutation 2, Jay L Degen
• MGI ID: MGI:3046446
• Synonyms: Fibgamma^390-396A, Fibgamma^delta5
• Gene: Fgg Location: Chr3:82915031-82922356 bp, + strand Genetic Position: Chr3, 36.94 cM
• Alliance: Fgg^tm2Jld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90908
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The DNA sequence in exon 9 encoding amino acid residues 390-396 (NRLSIGE) were modified to change these amino acids to a series of 7 alanines. This removes the alpha-m-beta-2 binding motif. (J:90908)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgg Mutation: 30 strains or lines available

References

• Original: J:90908 Flick MJ, et al., Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo. J Clin Invest. 2004 Jun;113(11):1596-606
• All: 20 reference(s)