Rho^tm1Jhw
Targeted Allele Detail

Summary

• Symbol: Rho^tm1Jhw
• Name: rhodopsin; targeted mutation 1, John H Wilson
• MGI ID: MGI:3046185
• Gene: Rho Location: Chr6:115908709-115916997 bp, + strand Genetic Position: Chr6, 53.72 cM
• Alliance: Rho^tm1Jhw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91038
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous gene was replaced with an HPRT minigene flanked by loxH and lox511 sites via homologous recombination. (J:91038)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rho Mutation: 48 strains or lines available

References

• Original: J:91038 Chan F, et al., Knock-in human rhodopsin-GFP fusions as mouse models for human disease and targets for gene therapy. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9109-14
• All: 1 reference(s)