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NciltO20/A
QTL Variant Detail
Summary
QTL variant: NciltO20/A
Name: nuclear cytoplasmic invaginations in lung tumors; O20/A
MGI ID: MGI:3045606
QTL: Ncilt  Location: Chr6:145162425-145195965 bp  Genetic Position: Chr6, Syntenic
Variant
origin
Strain of Specimen:  O20/A
Variant
description
Allele Type:    QTL
Notes
Homozygosity for O20/A-derived alleles at this locus is associated with the presence of nuclear cytoplasmic invaginations (NCIs) in lung tumors.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:68464

Linkage analysis was performed on F2 crosses derived between 3 different OcB/Dem recombinant congenic strains (OcB-4/Dem, OcB-6/Dem, OcB-9/Dem) and O20/A to identify QTLs associated with susceptibility to lung tumors. (The OcB/Dem RC strains are derived from progenitor strains O20/A and B10.O20.) Parental strain O20/A is susceptible to lung tumors whereas parental strain B10.O20 is resistant. F2 animals were treated with ENU in utero and lung tumors were assessed for nuclear cytoplasmic invaginations (NCI) and lymphocytic infiltration (LI).

Linkage to NCI was observed in the (OcB-6/Dem x O20/A)F2 cross at the Kras locus (P=0.0456) at 71 cM on mouse Chromosome 6. This locus is named Ncilt (nuclear cytoplasmic invaginations in lung tumors.) Inheritance of 2 B10.O20-derived alleles at Kras is strongly correlated with the presence of NCI in lung tumors whereas inheritance of 2 O20/A-derived alleles is strongly correlated with the absence of NCI in lung tumors. In this cross, the presence of NCIs is seen insmaller tumors whereas the presence of LI is seen in larger tumors.

References
Original:  J:68464 Tripodis N, et al., Genetic linkage of nuclear morphology of mouse lung tumors to the Kras-2 locus. Exp Lung Res. 2001 Apr-May;27(3):185-96
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory