Del(11Jmjd6-Mettl23)1Ysfk
Targeted Allele Detail

Summary

• Symbol: Del(11Jmjd6-Mettl23)1Ysfk
• Name: deletion, Chr 11, Yoshinori Fukui 1
• MGI ID: MGI:3043930
• Synonyms: Jmjd6^tm1Ysfk, PSR-
• Gene: Del(11Jmjd6-Mettl23)1Ysfk Location: unknown Genetic Position: Chr11, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90288
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(11Jmjd6-Mettl23)1Ysfk involves 2 genes/genome features (Jmjd6, Mettl23) View all
• Mutation details: A 2.8 kb segment including exons 1, 2 and part of exon 3 was replaced with a neo cassette via homologous recombination. Northern blot analysis confirmed the absence of RNA expression in homozygotes. A subsequent publication demonstrated that the neo cassette also replaced the first exon of the neighboring gene, Mettl23, located on the opposite strand. RT-PCR confirmed absence of Mettl23 mRNA in homozygous embryos. (J:90288, J:137989)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(11Jmjd6-Mettl23)1Ysfk Mutation: 0 strains or lines available

References

• Original: J:90288 Kunisaki Y, et al., Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor. Blood. 2004 May 1;103(9):3362-4
• All: 4 reference(s)