Igf2bp1^{Gt(OST33739)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Igf2bp1^{Gt(OST33739)Lex}
• Name: insulin-like growth factor 2 mRNA binding protein 1; gene trap OST33739, Lexicon Genetics
• MGI ID: MGI:3043746
• Synonyms: Igf2bp1^{Gt(Betageo)1Fcn}, Imp1^-, Imp1^Beta-geo, Zbp1^-
• Gene: Igf2bp1 Location: Chr11:95847989-95896766 bp, - strand Genetic Position: Chr11, 59.08 cM
• Alliance: Igf2bp1^{Gt(OST33739)Lex} page

Mutation origin

• Mutant Cell Line: OST33739
• Germline Transmission: Earliest citation of germline transmission: J:89882
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A retroviral gene trap vector, containing a 5' LTR followed by a splice acceptor, beta-geo, PGK-puro, stop codons, a splice donor, and a 3' LTR, was inserted into intron 2. Insertion of the gene trap vector led to deletion of the second RNA recognition motif and the four K-homology modules, known to be essential for RNA binding, cytoplasmic granule formation, and subcytoplasmic localization. Normal transcript was undetected by RT-PCR analysis of homozygous mutant embryos. (J:89882)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST33739	CG494710 ; (MGI Seq Detail)	3' RACE	Chr11:95864820-95870494 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  133 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	75 assay results
In Structures Affected by this Mutation:	19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 1 line available
• Carrying any Igf2bp1 Mutation: 102 strains or lines available

Notes

See also, data as provided by Lexicon Genetics, Inc.

References

• Original: J:89882 Hansen TV, et al., Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice. Mol Cell Biol. 2004 May;24(10):4448-64
• All: 7 reference(s)